Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation
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چکیده
منابع مشابه
Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation
Primate lentiviruses have evolved sophisticated strategies to suppress the immune response of their host species. For example, HIV-2 and most simian immunodeficiency viruses (SIVs) use their accessory protein Nef to prevent T cell activation and antiviral gene expression by downmodulating the T cell receptor CD3. This Nef function was lost in HIV-1 and other vpu-encoding viruses suggesting that...
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ژورنال
عنوان ژورنال: PLOS Pathogens
سال: 2017
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1006598